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The one-instanton contribution to the prepotential for N = 2 supersymmetric gauge theories with classical groups exhibits a universality of form. We extrapolate the observed regularity to SU (N) gauge theory with two antisymmetric hypermultiplets and Nf ≤ 3 hypermultiplets in the defining representation. Using methods developed for the instanton expansion of non-hyperelliptic curves, we construct an effective quartic Seiberg-Witten curve that generates this one-instanton prepotential. We then interpret this curve in terms of an M-theoretic picture involving NS 5-branes, D4-branes, D6-branes, and orientifold sixplanes, and show that for consistency, an infinite chain of 5-branes and orientifold sixplanes is required, corresponding to a curve of infinite order. © 1999 Elsevier Science B.V. All rights reserved.